Fig. 4: Cycloheximide (CHX) pre-treatment does not alter ribosome occupancy downstream of rare codons in most species. | Nature Communications

Fig. 4: Cycloheximide (CHX) pre-treatment does not alter ribosome occupancy downstream of rare codons in most species.

From: Humans and other commonly used model organisms are resistant to cycloheximide-mediated biases in ribosome profiling experiments

Fig. 4: Cycloheximide (CHX) pre-treatment does not alter ribosome occupancy downstream of rare codons in most species.The alt text for this image may have been generated using AI.

a Transcriptome-wide ribosome enrichment profiles according to Hussmann et al. 33 using libraries generated from E14 mouse embryonic stem cells5, zebrafish embryos10, and wild-type yeast (this study) surrounding CGA and UUA codons and using different CHX treatment regimens. b Same as a for long footprints of HEK 293T cells. c Same as a for published human ribosome profiling datasets19, 20, 58,59,60,61,62,63. d Same as a for the CGA codon in C. albicans and S. pombe (this study). This plot only uses long footprints (28–32 nt).

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