Fig. 4: Asymmetric biomimetic transamination of α-keto amides.

TBDPS = tert-butyldiphenylsilyl. ^aReaction conditions: 2 (0.10 mmol), 4 (0.11 mmol), 1b (0.0050 mmol), HOAc (0.40 mmol), Na₂HPO₄ or KOAc (0.20 mmol) in CF₃CH₂OH or MeOH (0.48 mL) and H₂O (0.12 mL) for 48 or 72 h unless otherwise stated (See SI). For 3m-y, the reactions were carried out in a double scale. Isolated yields were based on α-keto amides 2. The ee and dr values were determined by HPLC analysis. ^bThe crude reaction mixture was treated with di-tert-butyl dicarbonate (0.30 mmol) at room temperature for 3 h. ^cThe reaction was carried out in a double scale with 7 (0.040 mmol, 20 mol %) at 50 °C for 72 h.