Fig. 5: Bactosensor-based pathological bile salt detection in clinical samples. | Nature Communications

Fig. 5: Bactosensor-based pathological bile salt detection in clinical samples.

From: Programmable receptors enable bacterial biosensors to detect pathological biomarkers in clinical samples

Fig. 5

a Serum samples from 21 liver transplantation patients being followed at a Montpellier hospital were analyzed using a bactosensor equipped with the TcpP18–LacZ sensor as described in Fig. 4a, with a 10-fold dilution and 2 h incubation time (Supplementary Fig. 14). b Comparing the analysis result of 21 clinical serum samples between TcpP18–LacZ and a bile salt assay kit. The response of TcpP18–LacZ is shown in purple bars, left axis. The serum total bile salt concentration measured by a bile salt enzymatic assay kit is labeled in green asterisks, right axis. The bar graph corresponds to the mean value of three replicates performed in triplicate on three different days (n = 3 biologically independent samples). Error bars: ±SD. See Supplementary Fig. 18 for plots with all replicates represented.

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