Table 1 Pathway analysis of the co-downregulated proteins (n = 413) at +24 and +48 h in Nalm-6 cells cocultured with 3T3-L1 adipocytes, as detected by pulsed SILAC. Pathway enrichment was assessed by two-sided Fisher’s exact tests with a Benjamini–Hochberg FDR of 5%. Pathways with an enrichment >2 are presented.

From: Adipocytes disrupt the translational programme of acute lymphoblastic leukaemia to favour tumour survival and persistence

 

Category

Pathway

Enrichment factor

P-value

Benj. Hoch. FDR

1

Keywords

Elongation factor

3.1071

0.00034546

0.01708

2

GOCC

chaperonin-containing T-complex

3.1071

0.0001099

0.003187

3

Keywords

rRNA-binding

2.7618

0.00067496

0.026323

4

GOCC

cytosolic small ribosomal subunit

2.3052

1.25E−06

6.84E−05

5

GOCC

small ribosomal subunit

2.2597

1.31E−06

6.84E−05

6

GOBP

positive regulation of translation

2.244

0.00044973

0.036325

7

GOBP

regulation of cysteine-type endopeptidase activity

2.1749

0.00044019

0.036147

8

KEGG

Ribosome

2.1128

4.68E−11

1.04E−08

9

GOBP

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

2.0963

7.60E−12

7.49E−09

10

GOBP

nuclear-transcribed mRNA catabolic process

2.0714

1.11E−12

2.73E−09

11

GOBP

mRNA catabolic process

2.0605

1.02E−12

2.73E−09

12

Keywords

Citrullination

2.0315

0.00035833

0.01708

13

GOCC

cytosolic large ribosomal subunit

2.0232

5.17E−06

0.00018405

14

GOCC

cell cortex part

2.0196

0.0019023

0.045137

15

GOBP

RNA catabolic process

2.0196

1.73E−12

2.83E−09

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