Fig. 1: TFE3 fusion isoforms and structures. | Nature Communications

Fig. 1: TFE3 fusion isoforms and structures.

From: Integrated exome and RNA sequencing of TFE3-translocation renal cell carcinoma

Fig. 1: TFE3 fusion isoforms and structures.The alt text for this image may have been generated using AI.

A The circle represents TFE3 gene fusions in our TFE3-tRCC cohort. B Exons and function domains for TFE3 gene (top). Protein domains are color-coded and depicted. Mapping of breakpoints onto the three-dimensional structure of TFE3 protein (bottom). C Exons and functional domains of the TFE3 and fusion partner genes detected in our TFE3-tRCC cohort. TFE3-tRCC TFE3-translocation renal cell carcinoma, AD strong transcription activation domain, bHLH basic helix–loop–helix domain, LZ leucine zipper domain, RRM RNA-recognition motif, SREBF1 Sterol Regulatory Element Binding Transcription Factor 1, MAD2L2 mitotic spindle assembly checkpoint protein MAD2B, KH K homology domain, Znf zinc-finger domains.

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