Fig. 10: Tonic inhibition in hippocampal and thalamic neurons is differentially dependent on spontaneous gating of GABAARs.
From: Structural determinants and regulation of spontaneous activity in GABAA receptors
a Left: current recording from a dentate gyrus granule cell (DGGC) in an acute hippocampal brain slice showing changes to baseline current when gabazine (20 µM) and PTX (100 µM) were applied. Right: Holding current density changes during antagonist application (**P = 0.0018; two-sided paired t-test; n = 9). b Left: current recording from a relay neuron of the dorsal lateral geniculate nucleus (dLGN) in an acute thalamic brain slice. Right: current density changes during antagonist application (*P = 0.032; two-sided paired t-test; n = 10). Data are presented as mean values ± SEM. *P < 0.05; **P < 0.01. Source data are provided as a Source Data file for Fig. 10.
