Table 1 Baseline characteristics.
Treatment group | |||
|---|---|---|---|
Placebo N = 33 | 500 mg BID N = 33 | 1000 mg BID N = 34 | |
Age (years) | |||
N | 33 | 33 | 34 |
Mean (SD) | 58 (10.7) | 58 (10.2) | 53 (12.2) |
Min, max | 40, 75 | 26, 75 | 27, 72 |
Sex–n (%) | |||
Male | 11 (33%) | 7 (21%) | 10 (29%) |
Female | 22 (67%) | 26 (79%) | 24 (71%) |
Race–n (%) | |||
White | 31 (94%) | 29 (88%) | 31 (91%) |
Black | 0 | 3 (9%) | 2 (6%) |
Other | 2 (6%) | 1 (3%) | 1 (3%) |
Ethnicity–n (%) | |||
Hispanic or Latino | 13 (39%) | 14 (42%) | 11 (32%) |
Not Hispanic or Latino | 20 (61%) | 19 (58%) | 23 (68%) |
Weight (kg) | |||
N | 33 | 33 | 34 |
Mean (SD) | 97.5 (22.57) | 98.4 (23.05) | 101.2 (20.26) |
Min, max | 70.8, 180 | 64.9, 154.1 | 71.7, 159.2 |
BMI (kg/m2) | |||
N | 33 | 33 | 34 |
Mean (SD) | 35.0 (6.18) | 36.7 (6.88) | 36.3 (6.28) |
Min, max | 25.4, 55.6 | 26.1, 55.9 | 25.4, 49.1 |
Liver fat content (%)* | |||
N | 32 | 33 | 34 |
Mean (SD) | 20.2 (6.23) | 18.4 (6.24) | 19.4 (6.96) |
Min, max | 11.1, 41.7 | 11.0, 43.48 | 9.0, 33.7 |
Corrected T1* | |||
N | 32 | 32 | 32 |
Mean (SD) | 940.8 (99.27) | 948.8 (119.53) | 932.4 (80.06) |
Min, max | 834.0, 1317.0 | 802.5, 1412.0 | 837.5, 1122.0 |
ALT (U/L) | |||
N | 33 | 33 | 34 |
Mean (SD) | 54 (26.7) | 46 (27.6) | 62 (31.8) |
Median | 47 | 39 | 55 |
Min, max | 17, 115 | 3, 141 | 24, 143 |
AST (U/L) | |||
N | 33 | 33 | 34 |
Mean (SD) | 38 (17.3) | 36 (15.9) | 45 (29.7) |
Median | 32 | 31 | 37 |
Min, max | 19, 88 | 15, 80 | 19, 147 |
GGT (U/L) | |||
N | 33 | 33 | 34 |
Mean (SD) | 70 (105.1) | 64 (50.7) | 68 (57.2) |
Median | 38 | 39 | 45 |
Min, max | 19, 618 | 18, 223 | 19, 263 |
HbA1c (%) | |||
N | 33 | 33 | 34 |
Mean (SD) | 7.0 (1.05) | 6.9 (0.85) | 7.3 (1.16) |
Median | 6.9 | 6.9 | 7.5 |
Min, max | 5.3, 9.4 | 5.5, 9.1 | 5.1, 9.3 |
LDL cholesterol (mg/dL)** | |||
N | 33 | 30 | 29 |
Mean (SD) | 99 (35.8) | 86 (29.4) | 107 (35.3) |
Median | 98 | 81 | 111 |
Min, max | 37, 188 | 26, 150 | 31, 168 |
Triglycerides (mg/dL)** | |||
N | 33 | 31 | 30 |
Mean (SD) | 197 (83.3) | 190 (204.6) | 174 (77.1) |
Min, max | 76, 423 | 54, 1217 | 58, 430 |
Fasting insulin (IU/mL) | |||
N | 33 | 33 | 34 |
Mean (SD) | 45.7 (34.64) | 30.8 (15.74) | 32.9 (16.43) |
Min, max | 6.2, 155.4 | 9.5, 70.7 | 9.6, 82.4 |
Fasting plasma glucose (mg/dL) | |||
N | 33 | 33 | 34 |
Mean (SD) | 136 (44.1) | 140 (39.9) | 155 (46.3) |
Min, max | 94, 313 | 89, 288 | 90, 268 |
