Fig. 6: Alternative genetic rearrangements leading to aberrant MAPK/ERK pathway signaling. | Nature Communications

Fig. 6: Alternative genetic rearrangements leading to aberrant MAPK/ERK pathway signaling.

From: Radiation-induced gliomas represent H3-/IDH-wild type pediatric gliomas with recurrent PDGFRA amplification and loss of CDKN2A/B

Fig. 6

Partial deletions of chromosomal arm 3p induce formation of a FYCO1:RAF1 fusion (a), with occurrence of a GKAP1:NTRK2 fusion (d) emerging through inversion of a chromosomal arm 9q segment. Both rearrangements are predicted to lead to constitutive activation of the kinase domain (KD). Induced by complex rearrangements, CAPZA2:MET (b) and PTPRZ1:MET fusion (c, e) contained almost the full length MET protein, with overexpression driven by the highly active CAPZA2 or PTPRZ1 promoter.

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