Fig. 7: Heatmap representing the expression levels of the 100 most significant, differentially expressed genes comparing RIG samples with reference groups (PXA, pedGBM_RTK1, pedGBM_RTK2, and pedGBM_MYCN). | Nature Communications

Fig. 7: Heatmap representing the expression levels of the 100 most significant, differentially expressed genes comparing RIG samples with reference groups (PXA, pedGBM_RTK1, pedGBM_RTK2, and pedGBM_MYCN).

From: Radiation-induced gliomas represent H3-/IDH-wild type pediatric gliomas with recurrent PDGFRA amplification and loss of CDKN2A/B

Fig. 7: Heatmap representing the expression levels of the 100 most significant, differentially expressed genes comparing RIG samples with reference groups (PXA, pedGBM_RTK1, pedGBM_RTK2, and pedGBM_MYCN).

Unsupervised hierarchical clustering reveals that gene expression profiling reflects our aforementioned findings based on DNA methylation profiling, with most RIGs resembling the pedGBM_RTK1 subgroup and a small subset more similar to PXAs. Each column represents one sample and each lane represents one gene. Expression levels are indicated by a color scale as indicated. PXA pleiomorphic xanthoastrocytoma, pedGBM_RTK1 pediatric glioblastoma subclass RTK1, pedGBM_RTK2 pediatric glioblastoma subclass RTK2, pedGBM_MYCN pediatric glioblastoma subclass MYCN.

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