Table 2 Tissue specificity for replicated genes encoding drug targets.

APOA5

2.05 (1.4–3.02)* ^†

0.72 (0.6–0.87)* ^†

1.21 (1.12–1.31)* ^†

1.00

Liver

SLC12A3

1.94 (1.43–2.63)*

0.89 (0.86–0.93)* ^†

0.75 (0.24–2.33)

0.98

Kidney

CEACAM16

1.66 (1.31–2.11)* ^†

0.46 (0.27–0.79)*

0.56 (0.25–1.27)

0.98

Pancreas, tonsil

APOC3

2.04 (1.72–2.42)* ^†

0.67 (0.58–0.78)*

1.26 (1.12–1.41)* ^†

0.95

Liver

APOA4

1.51 (1.23–1.86)* ^†

0.53 (0.38–0.74)*

1.27 (1.14–1.43)* ^†

0.94

Small intestine, colon, duodenum

APOB

1.5 (1.18–1.9)* ^†

1.23 (0.72–2.12)

0.53 (0.29–0.98)* ^†

0.94

Liver, small intestine

APOA1

1.88 (1.49–2.36)* ^†

0.84 (0.63–1.11)

1.25 (1.12–1.4)* ^†

0.93

Liver, small intestine

NPC1L1

2.01 (1.48–2.73)* ^†

–

2.56 (0.75–8.68)

0.92

Small intestine, colon, duodenum, liver

GPR61

1.97 (1.56–2.5)* ^†

3.02 (0.77–11.91)

5.14 (1.43–18.48)*

0.91

Cerebral cortex, adrenal gland, eye, thyroid gland

PCSK9

1.6 (1.45–1.77)* ^†

–

–

0.87

Liver, lung, pancreas

APOC1

1.31 (1.22–1.41)* ^†

0.39 (0.25–0.59)*

0.51 (0.17–1.47)

0.85

Liver

CETP

1.49 (1.29–1.72)*

0.91 (0.87–0.95)* ^†

1.98 (1.63–2.4)* ^†

0.76

Lymph node, liver, placenta, spleen

ADAMTS13

11.18 (4.37–28.59)* ^†

–

-

0.72

Liver

CILP2

1.19 (1.01–1.39)*

–

1.18 (1.0–1.39)* ^†

0.71

Testis, gallbladder, ovary, thyroid gland

LPL

–

0.63 (0.49–0.82)* ^†

1.68 (1.46–1.92)* ^†

0.68

Adipose tissue, breast, heart muscle, seminal vesicle

APOE

1.3 (1.2–1.41)* ^†

0.39 (0.26–0.59)*

0.5 (0.17–1.45)

0.58

Liver, adrenal gland

CELSR2

1.97 (1.78–2.18)* ^†

0.06 (0.04–0.09)*

–

0.58

Cerebral cortex, fallopian tube, skin

ALDH1A2

–

0.89 (0.81–0.99)*

1.28 (1.07–1.54)* ^†

0.55

Endometrium, blood, cervix, uterine, fallopian tube, eye, seminal vesicle, testis

ANGPTL4

–

0.48 (0.28–0.83)* ^†

3.38 (1.02–11.22)* ^†

0.50

Liver, adipose tissue, breast, cerebral cortex, pancreas

PVR

1.31 (1.12–1.54)* †

0.32 (0.11–0.91)*

–

0.45

Liver, heart muscle

NDUFA13

1.63 (1.13– 2.35)*

–

1.18 (1.0–1.39)* ^†

0.43

Testis, blood, heart muscle, skeletal muscle

CARM1

2.27 (1.68–3.05)* ^†

–

–

0.38

Skeletal muscle

VEGFA

-

0.22 (0.15–0.3)*

4.16 (2.45–7.08)* ^†

0.33

Thyroid gland, endometrium, heart muscle, liver, skeletal muscle, urinary bladder

SIK3

1.15 (0.57–2.31)

0.46 (0.29–0.73)* ^†

1.08 (0.98–1.18)

0.27

Cerebral cortex, ovary, parathyroid gland, testis, thyroid gland

TMED1

2.06 (1.5–2.83)* ^†

–

–

0.26

Blood, heart muscle, liver, placenta, skeletal muscle

PSMA5

2.47 (1.8–3.39)* ^†

0.08 (0.02–0.29)*

–

0.23

Liver, cerebral cortex, kidney, skeletal muscle, thyroid gland

SMARCA4

2.22 (1.98–2.49)* ^†

0.01 (0.0–0.02)*

–

0.19

Cerebral cortex, bone marrow, esophagus, skeletal muscle, skin, testis, tonsil

RPL7A

2.29 (1.57–3.36)* ^†

–

–

0.19

Salivary gland, endometrium, lymph node, ovary, pancreas