Fig. 4: Structure of LRRC8A in complex with the inhibitory sybody Sb1.
From: Allosteric modulation of LRRC8 channels by targeting their cytoplasmic domains
a Surface representation of the LRRC8A/Sb1 complex structure. b Structure of the dimer of interacting domains at the tight interface with bound sybody Sb1. Left (l) and right (r) positions are indicated. c Ribbon representation of the LRRC8A/Sb1 complex. a, c The view is from within the membrane with membrane boundaries indicated. d Ribbon representation of a single LRR domain with sybody Sb1 bound. Repeats contacted by Sb1 are labeled. e View on the interaction interface of Sb1 and f the LRRC8A domain. The protein is shown as Cα trace with the sidechains of interacting residues displayed as sticks.
