Fig. 2: TI performance comparisons on complex hybrid topologies.
From: Generalized and scalable trajectory inference in single-cell omics data with VIA
a Topologies of four representative synthetic datasets (Multifurc1, Cyclic1, Disconn1, and Conn1) output by different TI methods. The reference topologies are shown on the left. Each dataset contains 1000 “cells” and is run with ten PCs and KNN = 20. VIA is shown at the cluster graph level but can also be projected to the single-cell level as shown in later examples. b Composite accuracy score is shown for each method across all nine synthetic datasets (detailed breakdown available in Supplementary Figs. 2–5). Note STREAM does not work on the Disconnected data (producing highly distorted results) and therefore excluded in Disconn1 and Disconn2.
