Table 3 Discriminatory performance (%) of the predicted BMD to classify hip/lumbar vertebral osteoporosis and high-risk groups for major osteoporotic or hip fractures.
Discriminatory measures | Hip osteoporosis (T-score ≤ −2.5 | Lumbar vertebral osteoporosis (vertebrae with the lowest T-score ≤2.5) | 10-year risk of major osteoporotic fracture ≥20% | 10-year risk of hip fracture ≥3% |
|---|---|---|---|---|
Number of patients, % | 1110, 21.5 | 7860, 43.3 | 530, 10.4 | 2254, 44.2 |
OR (95% CI) | 74.80 (61.05–91.65) | 38.22 (35.12–41.59) | 107.92 (81.98–142.06) | 79.29 (66.03–95.24) |
AUROC/AUPRC | 0.97/0.89 | 0.92/0.89 | 0.97/0.83 | 0.97/0.96 |
Accuracy (%; 95% CI) | 91.7 (90.9–92.5) | 86.2 (85.7–86.7) | 95.0 (94.3–95.6) | 90.0 (89.1–90.8) |
Sensitivity (%; 95% CI) | 80.2 (77.7–82.5) | 83.5 (82.7–84.3) | 69.6 (65.5–73.5) | 88.2 (86.8–89.5) |
Specificity (%; 95% CI) | 94.9 (94.1–95.5) | 88.3 (87.7–88.9) | 97.9 (97.5–98.3) | 91.4 (90.3–92.4) |
PPV (%; 95% CI) | 81.1 (78.9–83.1) | 84.5 (83.8–85.2) | 79.5 (76.0–82.7) | 89.1 (87.8–90.2) |
NPV (%; 95% CI) | 94.6 (94.0–95.2) | 87.6 (87.0–88.0) | 96.5 (96.1–96.9) | 90.7 (89.7–91.6) |
