Table 1 Association between chromosomal damage and parity.

From: Parity associates with chromosomal damage in uterine leiomyomas

Responsea

Tumorsb

n tumors

n patients

P (adjustedc)

Model

Effect [95% CI]d (adjustedc)

Total AI region length (bp)

All

1836

595

1.02e-07

Poisson

1.32 [1.15–1.52]

Total AI region length (bp)

MED12

1442

429

0.0088

Poisson

1.39 [1.05–1.84]

Total AI region length (bp)

WT

394

306

1

Poisson

1.05 [0.9–1.22]

CCR status (yes/no)

All

1836

595

0.000154

Binomial

1.29 [1.09–1.52]

CCR status (yes/no)

MED12

1442

429

0.00572

Binomial

1.465 [1.07–2.0]

CCR status (yes/no)

WT

394

306

1

Binomial

0.953 [0.754–1.2]

Whole chromosome loss (yes/no)

WT

394

306

0.0015

Binomial

1.64 [1.13–2.36]

  1. bp base pairs, AI allelic imbalance, CCR complex chromosomal rearrangements.
  2. aParity is the predictor. Confounders: history of ever smoking (yes/no), age, menopause status (pre/hormonal replacement therapy/post), and combined oral contraceptive use (never/ever).
  3. bAll: all tumors regardless of mutation status; MED12: only the MED12 mutation-positive tumors; WT: only the MED12 mutation-negative tumors.
  4. cBonferroni adjusted two-sided P-values and 95% confidence intervals (adjusted alpha 0.05/11).
  5. dFor binomial regression, odds ratio is reported and for Poisson regression rate ratio.
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