Fig. 3: Fitness landscapes for multiple functional parameters in response to induction with naringenin.
From: Epistasis shapes the fitness landscape of an allosteric specificity switch
Fitness landscapes of (a) fold induction, (b) basal gene expression, (c) maximum gene expression, and (d) EC50 parameters for all 16 TtgR variants in response to naringenin with each variant shown as a node in the graph. The labeling and line colors are analogous to Fig. 2. Nodes are shaded by log10 of the fitness parameter at 2000 μM naringenin normalized to the fitness of wild type TtgR. Number of epistatic subnetworks in the resveratrol (e) fold induction, (f) basal gene expression, (g) maximum gene expression, and (h) EC50 landscape determined by Bahadur expansion. The labels of the pie charts are identical to Fig. 2.
