Fig. 4: Structural basis for ligand specificity.
From: Epistasis shapes the fitness landscape of an allosteric specificity switch
Wild-type TtgR and quadruple mutant are shown in blue and green ribbons, respectively. Positions 137, 141, 167, and 168 are colored in pink. Resveratrol is shown as gray sticks. Water molecules are shown as red spheres. a Binding pocket of resveratrol-bound wild-type TtgR (PDB ID: 7K1C) (upper panel) with residues making hydrogen bonds to resveratrol highlighted in orange (lower panel). b Binding pocket of resveratrol-bound quadruple mutant TtgR (PDB ID: 7KD8) (upper panel) with residues making hydrogen bonds to resveratrol highlighted in orange (lower panel).
