Fig. 2: D3-31 mice are protected from T cell-dependent autoimmunity in a sex-specific manner. | Nature Communications

Fig. 2: D3-31 mice are protected from T cell-dependent autoimmunity in a sex-specific manner.

From: Polymorphic estrogen receptor binding site causes Cd2-dependent sex bias in the susceptibility to autoimmune diseases

Fig. 2

Collagen-induced arthritis (CIA) in a female and b male BR and D3-31 mice. Data was pooled from two independent experiments. Delayed-type hypersensitivity (DTH) reaction in c female and d male BR and D3-31 mice. Box upper and lower limits indicate interquartile range (25th/75th percentiles), the middle line indicates the median. Whiskers indicate 10th and 90th percentiles. Min. and max. values are plotted as individual dots. Data is representative of three independent experiments with similar results. MBP89-101-induced experimental autoimmune encephalomyelitis (EAE) in e female and f male BR and D3-31 mice. Data was pooled from two independent experiments. For all graphs, incidence and total number of mice used are indicated in parenthesis. Data are summarised as mean (SEM). Statistical significance was evaluated using a two-tailed non-parametric Mann–Whitney U test.

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