Table 1 Characterization the physiochemical properties of SMC #13 and drug-likeness potential using the SwissADME online tool.

From: Targeting the actin nucleation promoting factor WASp provides a therapeutic approach for hematopoietic malignancies

Parameters

 

Molecular weight

461.6 g/mol

No. of H bond acceptors

4

No. of H bond donors

0

Topological polar surface area (TPSA)

53.09 Å

Partition coefficient—Log P

3.78

Solubility—Log S

−5.44

GI absorption

High

BBB permeant

Yes

P-gp substrate

No

Drug likeness

Yes

Bioavailability score

0.55

  1. GI Gastrointestinal, BBB brain–blood barrier, P-gp P-glycoprotein.
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