Fig. 1: Integrative multi-omic analysis of thyroid cancer cohort.
From: Chromatin accessibility associates with protein-RNA correlation in human cancer
a Cohort description, 93 samples of patient-matched samples of lymph-node metastases, primary thyroid tumors, and adjacent normal thyroid were assayed. Three omics are integrated to profile chromatin accessibility, transcript abundances, and protein abundance. b Analytical framework, assay for transposase-accessible chromatin using sequencing (ATAC-seq), RNA-seq, and proteomics resulted in measurements for 5384 genes, which were used in correlation analyses across omics. c Visualization of the omic data for thyroglobulin (TG). Biologically independent tissue chunks from each disease stage (i.e., normal, tumor, and met) are averaged to produce the signal plots. d Distribution of protein–RNA correlation comparing all genes vs differentially expressed genes. e Distribution of RNA abundance for bins of protein–RNA correlations. f Gene-wise correlation of differentially expressed genes at the RNA level and differentially expressed proteins across all pairwise comparisons.
