Fig. 3: Association of gene accessibility with RNA and protein abundances.

a Schematic of the gene accessibility metric. b Visualization of gene accessibility and RNA and protein abundances for MET gene (top) and FN1 gene (bottom). Sample size; normal ATAC = 28, tumor ATAC = 30, met ATAC = 35, normal RNA = 27, tumor RNA = 30, met RNA = 30, normal protein = 21, tumor protein = 22, and met protein = 22. c Density of co-correlation between gene accessibility and gene expression. d Gene-wise correlation for genes with differential gene accessibility. e Frequency of exonic non-promoters and intronic non-promoters for differentially accessible genes (left) and distribution of the ratio of exonic length to intronic length for differentially accessible genes (right). f Comparison of exonic non-promoters (top) vs intronic non-promoters’ sample-wise correlation (bottom).