Fig. 1: Interaction network within PICS complex.
From: Molecular basis for PICS-mediated piRNA biogenesis and cell division
a Domain architecture of PICS subunits, TOFU-6, PICS-1(PID-3), ERH-2, and TOST-1 or PID-1. Domain boundaries are numbered and interactions between PICS subunits are indicated by grey dash arrows. IBM: IFE-3 binding motif. Functions of TOST-1- and PID-1- containing complexes are different. b ITC binding curves for PICS-1RRM  with TOFU-6RRM. c Overall structure of TOFU-6RRM/ PICS-1RRM heterotetramer. Two PICS-1RRM molecules are shown in red and cyan cartoon, respectively, while the two TOFU-6RRM molecules are shown in orange and green cartoon, respectively. d Interface of PICS-1RRM homodimer. Two PICS-1RRM molecules are shown in the same way as in Fig. 1c. e Detailed interactions between two PICS-1RRM protomers in the homodimer. Residues involved in intermolecular interactions are shown in sticks  with hydrogen bonds shown in black dashes.
