Fig. 7: piRNA biogenesis depends on the interactions between PICS subunits.
From: Molecular basis for PICS-mediated piRNA biogenesis and cell division
a 21U-RNA levels are detected by quantitative RT-PCR with RNA levels normalized to total reverse transcribed RNAs. Mean ± SD; ***p < 0.001, **p < 0.01, *p < 0.05; ns, not significant; n = 4 replicates; two-tailed paired t-tests. b A working model for PICS complex. PICS complex consists of four core subunits, and functions in chromosome segregation and piRNA biogenesis via two mutually exclusive factors, TOST-1 and PID-1, respectively.
