Fig. 6: Lung-specific response of 8-week-old and 9-month-old male BALB/c mice during MASCp36 infection. | Nature Communications

Fig. 6: Lung-specific response of 8-week-old and 9-month-old male BALB/c mice during MASCp36 infection.

From: Characterization and structural basis of a lethal mouse-adapted SARS-CoV-2

Fig. 6: Lung-specific response of 8-week-old and 9-month-old male BALB/c mice during MASCp36 infection.

a Multiplex immunofluorescence staining for detection of SARS-CoV-2 N protein (red), Cleaved caspase-3 (white), and SPC (green) expression in lung tissues of male mice (9-month-old and 8-week-old) at 1 dpi. The green arrows indicate apoptotic cells with MASCp36 infection in the alveolar region (n = 3 per group) b Multiplex immunofluorescence staining for CD68+ macrophages and Ly-6G+ neutrophils infiltration in 9-month-old mice and 8-week-old mice after infection at 1 and 4 dpi. Less CD68+ macrophages and Ly-6G+ neutrophils were detected in 9-month-old mice than that in young mice 1 dpi, and reversed on 4 dpi (n = 3 per group).

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