Fig. 7: The efficacy of H014 against MASCp36 infection.
From: Characterization and structural basis of a lethal mouse-adapted SARS-CoV-2
Male BALB/c mice (9-month-old) infected with 1200 PFU of MASCp36. a Survival curves of mice in H014 and mock treatment groups (n = 5 per group). Statistical significance was analyzed by Log-rank (Mantel–Cox) test (P = 0.0023, **P < 0.01). b Lung samples were collected at 4 dpi and subjected to viral RNA load analysis by RT-qPCR. The result were presented as mean ± SD. Dash lines denote the detection limit (n = 3 per group). c Multiplex immunofluorescence staining of mouse lung sections for detection of SARS-CoV-2 N protein (red), SPC (green), and Ly6G (white) (n = 3 per group). d H&E staining of lung sections from H014 or isotype control (n = 3 per group).
