Fig. 1: Central AdipoR function controls animal growth.

a Scheme of AdipoR-positive neurons (APNs) and their projections on the corpora allata of the ring gland. b Measure of larval wing disc size 96 h after egg laying (AEL) from Apn > AdipoR-Ri (n = 45, red) and Apn > (n = 52, black). c Measure of adult wing size of Apn > AdipoR-Ri (n = 51, red) and Apn > (n = 47, black). n = biologically independent samples from five (b) and three (c) independent experiments. Statistical significance was tested using ordinary two-way ANOVA with Sidak’s multiple comparisons test. d Measure of adult weight of Apn > AdipoR-Ri (n = 9, red), Apn > (n = 20, black), >AdipoR-Ri (n = 9, gray), >AdipoR-act (n = 10, gray), Apn > AdipoR-act (n = 14, orange), lpp > (n = 4, black), >hAdipoQ (n = 5, gray) and lpp > hAdipoQ (n = 5, red). n = groups of 5–10 males. Statistical significance was tested ordinary one-way ANOVA with Tukey’s multiple comparisons test. e APN activity levels at 96 h AEL revealed by anti-GFP immunostaining and quantified by GFP fluorescence intensity using a UAS-CaLexA probe (see Methods) in different sugar diets (LSD, ND, HSD), upon modulation of AdipoR expression in LSD (in f) or upon human AdipoQ feeding (in g). Quantifications are shown in accompanying panels (e, LSD n = 16, orange; ND n = 17, black; HSD n = 16, red), (f, Apn > AdipoR-Ri n = 17, orange; Apn > n = 12, black), (g; +hAdipoQ n = 20, red squares; control n = 18, red points). n = number of independent GFP measurements. Statistical significance was tested using a two-sided Mann–Whitney test. Data were presented as mean values ± SEM. P values are indicated in all panels. a.u. arbitrary units. Source data are provided as a Source Data file.