Fig. 2: HER2 and RAB GTPase expression in cell lines.
From: RAB5A expression is a predictive biomarker for trastuzumab emtansine in breast cancer
A Representative Western blot of HER2 and γ-tubulin expression in SK-BR-3, SKOV-3, HCC1954, AU-565, MDA-MB-453, and MDA-MB-231 cells (n = 3). B Quantification of the HER2 Western blots relative to those of γ-tubulin. Data points represent the values of three independent experiments, the bars represent the average and the error bars represent the SD of the mean. C Linear regression analysis curve of HER2 protein expression and T-DM1 sensitivity (1/IC50(T-DM1)). D Representative western blot (n = 3) of RAB4A, RAB5A, RAB11A, and γ-tubulin expression in SK-BR-3, SKOV-3, AU-565, HCC1954, and MDA-MB-453 cells. E–G Quantification of the RAB4, RAB5, and RAB11 Western blots relative to those of γ-tubulin. Data points represent the values of three independent experiments, the bars represent the average and the error bars represent the SD of the mean. Source data are provided as a Source Data file.
