Fig. 5: Patient distribution within pCR and RAB5A expression in I-SPY2.
From: RAB5A expression is a predictive biomarker for trastuzumab emtansine in breast cancer
A Boxplots of RAB5A expression levels stratified by arm and pCR status (N = 83). The midline represents the median of RAB5 expression levels within each group (T-DM1 + pertuzumab-treated, no pCR: N = 22 independent samples; T-DM1 + pertuzumab-treated, pCR: N = 30 independent samples; trastuzumab + paclitaxel-treated, no pCR: N = 23 independent samples; trastuzumab + paclitaxel-treated, pCR: N = 8 independent samples). The upper and lower limits of the box correspond to the 1st and 3rd quartile of RAB5A expression, respectively, with whiskers extending to 1.5 times the interquartile range from top/bottom of the box. Dots represent expression values for each individual; and color reflects subtype (orange: HR+; green: HR−). B Mosaic plot showing patient distribution within the RAB5A RNA-high and -low based on the threshold of 9.76 by arm and pCR status. C–E The bayesian estimated pCR rates within the two treatment groups overall (C) as well as when divided in RAB5A RNA-high (D) and low (E) subsets. F, G ROC curves of the performance of RAB5A RNA as a biomarker in T-DM1 + pertuzumab-treated (F)- and trastuzumab + paclitaxel-treated (G) patients. Source data are provided as a Source Data file.
