Fig. 7: Predictive effects of RVGRS950 and RVGRS950LDLR− on CAD among UK Biobank participants. | Nature Communications

Fig. 7: Predictive effects of RVGRS950 and RVGRS950LDLR− on CAD among UK Biobank participants.

From: Calibrated rare variant genetic risk scores for complex disease prediction using large exome sequence repositories

Fig. 7

Odds ratios of RVGRS950 and RVGRS950LDLR− (i.e., RVGRS950 without LDLR) on CAD are shown for UK Biobank European participants. The same RVGRS with additional adjustment for a Framingham risk score and common variant genetic risk score (i.e., with full adjustment) are also shown. Squares represent the odds ratios that are expressed in terms of a 1 SD change in RVGRS. All odds ratios were calculated using a multivariable logistic regression model that was adjusted for age, age2, sex, and the first 20 principal components of ancestry. Horizontal lines indicate the 95% confidence interval of the odds ratio. OR indicates odds ratio, SD indicates standard deviation, CI indicates confidence interval, RVGRS950 refers to rare variant genetic risk score from the top 950 discovery genes, and RVGRS950LDLR− refers to rare variant genetic risk score from the top 950 discovery genes, excluding LDLR. LDLR refers to low-density lipoprotein receptor. Source data are provided as a Source data file.

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