Fig. 3: Pulmonary effects of direct intranasal challenge with SARS-CoV-2 variant B.1.1.7 in Syrian hamsters at 5 DPI.
From: ChAdOx1 nCoV-19 (AZD1222) protects Syrian hamsters against SARS-CoV-2 B.1.351 and B.1.1.7
a, b H&E staining, 20x, scale bar = 200 µm; a no pathology. b Focally extensive areas of bronchointerstitial pneumonia. c, d H&E staining, 200x, scale bar = 20 µm; c no pathology. d Bronchointerstitial pneumonia with alveolar histiocytosis, fibrin and edema. e, f IHC staining against N protein SARS-CoV-2 (brown) 200x, scale bar = 20 µm. e No staining. f Staining of bronchiolar epithelial cells, type I&II pneumocytes, and rare macrophages. Micrographs are representative of what was observed viewing 100% of a single 5 µm section of the complete lungs containing all lobes for each of four animals.
