Fig. 7: Pulmonary effects of direct IN challenge with SARS-CoV-2 variant B.1.351 in Syrian hamsters which received an IN or IM vaccine at 5 DPI. | Nature Communications

Fig. 7: Pulmonary effects of direct IN challenge with SARS-CoV-2 variant B.1.351 in Syrian hamsters which received an IN or IM vaccine at 5 DPI.

From: ChAdOx1 nCoV-19 (AZD1222) protects Syrian hamsters against SARS-CoV-2 B.1.351 and B.1.1.7

Fig. 7

a–c H&E 20x, scale bar = 200 µm; a no pathology. b, c general prevalence of interstitial pneumonia. d–f H&E 200x, scale bar = 20 µm; d No pathology e rare focus of interstitial pneumonia. f moderate interstitial pneumonia. g–i IHC staining against N protein SARS-CoV-2, 200x, scale bar = 20 µm. g No viral antigen. h Rare foci of viral antigen in type I pneumocytes. i Viral antigen within the larger area of interstitial pneumonia in type I pneumocytes. Micrographs are representative of what was observed viewing 100% of a single 5 µm section of the complete lungs containing all lobes for each of four animals.

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