Fig. 2: CD127+CD94+ cells localize in the lamina propria and express ILC and NK cell-related markers. | Nature Communications

Fig. 2: CD127+CD94+ cells localize in the lamina propria and express ILC and NK cell-related markers.

From: CD127+ CD94+ innate lymphoid cells expressing granulysin and perforin are expanded in patients with Crohn’s disease

Fig. 2: CD127+CD94+ cells localize in the lamina propria and express ILC and NK cell-related markers.

a Flow cytometry analysis of lymphocytes in the intraepithelial compartment and lamina propria of the intestine. ieILC1 are gated for as live CD45+lineage-CD56+ NKp44+CD103+ (purple gate), NK cells (blue), conventional ILCs (green) and CD127+CD94+ ILCs (red) are gated for as in Fig. 1a. Histograms depict the surface expression of CD103 and CD127 on the indicated populations. b Expression of surface phenotypes (CD94, CD127, CD56, CD16, CD161, CD117, NKp44, all at least N = 4) and intracellular Eomes (N = 3) and RORγt (N = 2) of intestinal CD127+CD94+ cells (red), CD127−CD94+ NK cells (blue) and CD127+ CD94− ILCs (green). c, d Violin plots showing the expression of TCF7, PRDM1, NKG7, IKZF3 (c), CCL3, CCL4, and CCL5 (d) of clusters identified clusters of Fig. 1.

Back to article page