Table 3 Evidence supporting druggable genes whose expression was significantly associated with a PD progression trait using the Wald ratio or IVW method.
Gene | PD outcome | Tissue | Sign. with max. lik. | Sign. with MR-Egger | MR-Egger intercept test | Cochran’s Q test | I2 test | pQTL evidence | Coloc |
|---|---|---|---|---|---|---|---|---|---|
RHD | Dyskinesia | Brain | ✓ | x | ✓ | ✓ | ✓ | ||
IRAK3 | Dyskinesia | Blood | ✓ | ✓ | ✓ | ✓ | ✓ | ||
Depression | Blood | ✓ | ✓ | x | ✓ | ✓ | |||
UPDRS part 2 | Blood | ✓ | x | x | ✓ | ✓ | |||
UPDRS part 4 | Blood | ✓ | ✓ | x | ✓ | ✓ | |||
ADAM32 | Hoehn and Yahr | Brain | ✓ | x | ✓ | ✓ | ✓ | ||
LMAN1 | UPDRS part 2 | Blood | ✓ | x | ✓ | ✓ | ✓ | ||
Dyskinesia | Blood | ✓ | ✓ | x | ✓ | ✓ | |||
PYGL | UPDRS part 4 | Brain | ✓ | ||||||
CD177 | Depression | Brain | |||||||
QDPR | UPDRS part 4 | Blood | ✓ | ✓ | ✓ | x | x | x | |
STK4 | Hoehn and Yahr | Brain | x | x | x |
