Fig. 2: Deletion of the δ subunit abrogates lethal C. albicans infection as monitored by MicroPET.
From: The δ subunit of F1Fo-ATP synthase is required for pathogenicity of Candida albicans
a CT, PET, and fused PET/CT images of NS-treated mice (n = 3) and WT-, atp16Δ/Δ-, and atp16Δ/ATP16-infected mice (n = 3) imaged with [18F]FDG (24, 48 and 72 h after infection). b Quantification of the in vivo PET signal intensity of NS-treated mice (n = 3) and WT-, atp16Δ/Δ-, and atp16Δ/ATP16-infected mice (n = 3) (24, 48 and 72 h after infection). c Normalization of the ratios of %ID/g in kidneys to those in the left thigh muscle (24, 48 and 72 h after infection). d The ex vivo biodistribution of [18F]FDG in the major organs of NS-treated mice (n = 3) and WT-, atp16Δ/Δ-, and atp16Δ/ATP16-infected mice (n = 3) injected with [18F]FDG (72 h after infection), as assessed with γ counter. Kidney l and Kidney r represent the left kidney and right kidney, respectively. In a one representative experiment of three independent experiments is shown. In b, c and d, data are expressed as the mean ± SD. *P < 0.05, ***P < 0.001; ns, not significant; by two-way ANOVA (b, c), or one-way ANOVA (d).
