Fig. 3: Efficient image-guided SLNs biopsy in rhesus macaque breast via folic-AIEgen.
From: Aggregation-induced emission luminogens for image-guided surgery in non-human primates
a Representative process of folic-AIEgen guided SLNs dissection from rhesus macaque. b Images of the lymphatic vessels (red arrows) and SLNs (red arrowheads) under white light (i, viii) and a handheld UV lamp (ii-vii). i and ii-Before injection, iii-2 min after injection of folic-AIEgen (700 µL, 40 µg/mL) into the right areola of macaque, iv-15 min after injection, v-Separation along the lymph vessel, vi-Exposure of the SLN, vii and viii- Dissection of the SLN. c Photographs of draining LN and adjacent LN obtained from digital camera and IVIS system. d Quantitative analysis of the fluorescence intensity of draining LN and adjacent LN. e Histological analysis of the draining LN and adjacent LN. Representative images of bright field, photoluminescence of frozen section at 488 nm excitation, and H&E staining of paraffin section. Scale bars = 100 μm. The experiment was repeated at least three times.
