Fig. 6: Image-guided surgery for small, peritoneal-disseminated SKOV3 tumors.
From: Aggregation-induced emission luminogens for image-guided surgery in non-human primates
a Representative process of folic-AIEgen guided dissection of tiny tumors in SKOV3-Luc xenograft-bearing nude mice (n = 3). At 24 h after intraperitoneal injection of folic-AIEgen (100 µL, 40 µg/mL), the intestinal tract of mice was carefully pulled out and the peritoneal SKOV3 microtumors were localized and resected under UV light. b Tumor co-localization (top) by the bioluminescence signals of SKOV3-Luc, fluorescence of folic-AIEgen. Image-guide tumor resection (middle) via the fluorescence of folic-AIEgen under 365 nm UV light (inner: the excised tumors). Bioluminescence imaging was performed on the mice again to confirm no residual lesions. H&E staining of the excised tumors (bottom). Scale bars = 1 mm. The experiment was repeated at least three times.
