Fig. 2: Overview of the primary infection and analysis of the establishment phase.

a The profile of circulating anodic antigen (CAA) and faecal egg output (eggs per gram, EPG) over the primary time course. Values are means ±  SE. Statistical comparisons made using one-sided Student’s t-test are indicated with brackets. For CAA values, P = 0.0009 (Wk6 versus Wk4), P = 0.0082 (Wk12 vs Wk10), P = 0.022 (Wk16 versus Wk12) and P < 0.0001 (Wk24 versus Wk16). For EPG values, P = 0.0203 (Wk8 versus Wk6), P = 0.0219 (Wk10 vs Wk8), P = 0.0109 (Wk10 versus Wk6) and P = 0.024 (Wk16 versus Wk10). Significance P < 0.05 *, <0.01 **, <0.001 ***, <0.0001 ****; n = 11 rhesus macaques, except Rh10. b The level of CAA in the bloodstream as an indicator of worm maturation in each animal over the establishment phase. The colours of plot lines denote stratification into Fast (red), intermediate (black) and Slow (blue) responder groups, plus Rh1 (green) based on cure rate; dotted line (^……) indicates the mean of all animals. c The peak value attained by the CAA level in each animal, its week post-infection and the predicted adult worm burden, estimated from ref. ⁴³. Rh10, with the highest values, was withdrawn from the study. d Mean weight change of Fast and Slow groups over the primary time course. The significance of the linear regressions was determined using an F-test with values over Weeks 0–6 not significant; Slow, weeks 6–12, P = 0.00049 (***); Fast, weeks 6–16, P = 0.0029 (**); n = 4 macaques from the Slow and 4 from the Fast groups. The percentage weight loss over the respective periods is indicated by brackets. e The pattern of egg detection in the faeces over the establishment phase for Fast and Slow groups, plus Rh1. Statistical comparisons using one-sided Student’s t-test, as above. P = 0.0394 and 0.0291 (Wk8 versus Wk6) for Fast and Slow groups, respectively. P < 0.05 *. Values are means ±  SE, n = 4 macaques from the Slow and 4 from the Fast groups. Source data are provided as a Source Data file.