Fig. 7: Enhanced mortality of 3-day-old schistosomula cocultured with rhesus plasma.

a The viability of 3-day-old schistosomula cultured for a further 48 h in the presence or absence of 33% v/v plasma, from Fast or Slow group animals, collected at the time points indicated over the post-infection period. Viability is expressed as % luminescence values of the test cultures, relative to the cultures without plasma. Values plotted are the means ±  SE, n = 4 macaques from the Slow and 4 from the Fast groups; three biological replicates were assayed. Statistical comparisons between Fast and Slow groups made at each time point using one-sided Student’s t-test; significance indicated by P < 0.05 *, <0.01**, <0.001***. b The viability of 3-day-old schistosomula cultured for a further 48 h in the presence or absence of 33% v/v plasma collected at the time points indicated over the post-challenge period. Values plotted are the means ±  SE; n = 11 rhesus macaques, excluding Rh10; three biological replicates were assayed. Statistical comparisons of % viability were made relative to the value at the Week 42 day of the challenge, using one-sided Student’s t-test with significances P < 0.05 *, <0.01**, <0.001***. c Control assay, showing the viability of 3-day-old schistosomula cultured for a further 48 h in the presence, relative to the absence of 33% v/v serum collected from permissive hamster animals infected with S. mansoni. Serum collected at time zero, and at 12- and 22-weeks post-infection; two biological replicates were assayed. Source data are provided as a Source Data file.