Fig. 4: TNBC subtypes differ in global methylation patterns and mesenchymal TNBCs show specific methylation for EZH2 targets and antigen presentation genes. | Nature Communications

Fig. 4: TNBC subtypes differ in global methylation patterns and mesenchymal TNBCs show specific methylation for EZH2 targets and antigen presentation genes.

From: Multi-omics analysis identifies therapeutic vulnerabilities in triple-negative breast cancer subtypes

Fig. 4: TNBC subtypes differ in global methylation patterns and mesenchymal TNBCs show specific methylation for EZH2 targets and antigen presentation genes.The alternative text for this image may have been generated using AI.

a Heatmap shows all differentially (FDR <0.05 and β-value>0.1) methylated CpGs by subtype. b Graph shows the number of differentially) hypomethylated and hypermethylated CpGs by TNBC subtype. c Barplots show the percentage of hypomethylated (blue) and hypermethylated (yellow) CpGs within each chromosome by TNBC subtype. d Pie charts show the distribution of differentially methylated CpG sites in each subtype by genomic location. e Starburst plots show gene expression and DNA methylation <3kb from promoter regions of corresponding genes. Significantly (FDR <0.05) hypo- and hyper-methylated promoter regions are colored in blue and yellow respectively, with genes of interest labeled in the plot. f Gene set enrichment analysis of genes negatively correlated with hypomethylated (blue) or hypermethylated (yellow) promoter methylation probes.

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