Fig. 3: The KLF5 and KLK2/3 super-enhancers display an inverse pattern of H3K27ac activation marks.
From: Opposing transcriptional programs of KLF5 and AR emerge during therapy for advanced prostate cancer
a, b Gene track views of H3K27ac and AR ChIP-seq data from AR-positive LNCaP and VCaP cell lines and the AR-negative PC-3 cell line at genomic loci for KLF5 and KLK2/KLK3. c, d Gene track views of H3K27ac from four clinical CRPC specimens at genomic loci for KLF5 and KLK2/KLK3. H3K27ac track heights were set using H3K27ac density at housekeeping gene enhancers shown in Supplementary Fig. 3.
