Fig. 6: Sensory-motor regions drive sharp transitions in functional connectivity dynamics (FCD).

A FCD-STD correlations obtained by correlating the first derivative of the FCD mean time course and the first derivative of the SW-STD time course of each cortical region. These correlations were performed for each HCP test participant and averaged across all runs and participants. B Same as A but simulated from pMFM using the best model parameters from the validation set and structural connectivity from the test set. The correlations were averaged across 1000 random simulations. C Correlation between empirical and simulated FCD-STD correlation spatial maps from B and C, showing strong correspondence between empirical and simulated results. D Casual perturbation of top 5 FCD-STD correlated regions (B) during the incoherent state (low FCD mean) led to a transition into the coherent state (high FCD mean). As a control analysis, perturbation of the bottom 5 FCD-STD correlated regions (B) during the incoherent state (low FCD mean) did not lead to a state change (FCD mean remains low). There are 297 independent samples for each boxplot in D. The boxes show the inter-quartile range (IQR) and the median. Whiskers indicate 1.5 IQR. Red crosses represent outliers. E Example FCD from the perturbation experiments. (Left) original incoherent state. (Middle) perturbation of top 5 FCD-STD correlated regions (sensory-motor drivers). (Right) perturbation of bottom 5 FCD-STD correlated regions. Source data are provided as a Source Data file.