Fig. 1: Transition-metal-catalyzed asymmetric coupling reactions to synthesize NSAID derivatives. | Nature Communications

Fig. 1: Transition-metal-catalyzed asymmetric coupling reactions to synthesize NSAID derivatives.

From: Catalytic enantioselective reductive domino alkyl arylation of acrylates via nickel/photoredox catalysis

Fig. 1: Transition-metal-catalyzed asymmetric coupling reactions to synthesize NSAID derivatives.

a The classical asymmetric cross-coupling with organometallic reagents. b Transition metal catalyzed asymmetric arylation of enol silane derivatives. c Nickel-photoredox co-catalyzed asymmetric reductive arylation of racemic α-chloro esters. d A complementary photoredox/nickel catalyzed enantioselective carboarylation of alkenes. e This work: Nickel/photoredox catalyzed reductive asymmetric alky arylation of acrylates.

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