Fig. 2: The crystal structure reveals the molecular basis of hnRNP L-SETD2 interaction.

a Ribbon representations of hnRNP L RRM2 bound to the SETD2^2167–2192 peptide. hnRNP L is colored in purple and the bound SETD2^2167–2192 peptide is colored in orange. b The SETD2^2167–2192 peptide is represented as ribbons on the molecular face of hnRNP L RRM2. The sidechains of SETD2^Leu2188 and SETD2 ^Leu2189 are shown as sticks. Red and blue colors denote negative and positive surface charges, respectively. The electrostatic potential surfaces were generated with PyMol at the contouring value of the potential from −52.3 to 52.3 kTe⁻¹. c–f Closeup views of the interactions between hnRNP L and the SETD2^2167–2192 peptide. (Left) The van der Waals surface views of hnRNP L-SETD2^2167–2192. hnRNP L (purple) and SETD2^2167–2192 (orange) are shown as ribbons with selected sidechains as sticks. The van der Waals surface of the hnRNP L is depicted as a semitransparent skin. The SETD2 peptide is represented as a stick diagram (orange). (Right) Hydrogen bonds are shown as black dashed lines.