Fig. 7: Mutating Leu–Leu in the SHI domain results in decreased interaction of SETD2 with RNA-binding proteins. | Nature Communications

Fig. 7: Mutating Leu–Leu in the SHI domain results in decreased interaction of SETD2 with RNA-binding proteins.

From: Structural basis of the interaction between SETD2 methyltransferase and hnRNP L paralogs for governing co-transcriptional splicing

Fig. 7: Mutating Leu–Leu in the SHI domain results in decreased interaction of SETD2 with RNA-binding proteins.

a, b GO-term analysis of proteins using ShinyGO (http://bioinformatics.sdstate.edu/go/) identified by MudPIT in the affinity-purification of SETD2C and SETD2C-LL mutant. c, d Heat maps showing the enrichment of pathways in the IPA (Ingenuity Pathway Analysis) and proteins in MudPIT analysis. The enrichment of proteins is normalized to the bait (SETD2C).

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