Fig. 1: Morbidity, cutaneous temperature, and mortality of K18-hACE2 mice after infections of SARS-CoV-2 and variants. | Nature Communications

Fig. 1: Morbidity, cutaneous temperature, and mortality of K18-hACE2 mice after infections of SARS-CoV-2 and variants.

From: SARS-CoV-2 B.1.1.7 (alpha) and B.1.351 (beta) variants induce pathogenic patterns in K18-hACE2 transgenic mice distinct from early strains

Fig. 1: Morbidity, cutaneous temperature, and mortality of K18-hACE2 mice after infections of SARS-CoV-2 and variants.

K18-hACE2 mice of both sexes (~1:1 ratio) were infected intranasally with USA-WA1/2020 (WA) of lineage A bearing 614D, New York-PV09158/2020 (NY) of lineage B.1.3 bearing 614G, USA/CA_CDC_5574/2020 (CA) of lineage B.1.1.7 or hCoV-19/South Africa/KRISP-EC-K005321/2020 (SA) of lineage B.1.351 at indicated doses in an ABSL-3 biocontainment. Data are expressed as mean ± s.e.m of 6–8 mice/group (WA (614D) (103 TCID50/mouse): n = 8 mice/group; WA (614D) (104 TCID50/mouse): n = 7 mice/group; NY (614G) (102 TCID50/mouse): n = 6 mice/group; NY (614G) (103 TCID50/mouse): n = 8 mice/group; CA (B.1.1.7) (102 TCID50/mouse): n = 6 mice/group; SA (B.1.351) (102 TCID50/mouse): n = 6 mice/group; naïve: n = 4 mice/group). *p < 0.05 and **p < 0.01 by two-way mixed ANOVA (cutaneous temperature change) or by Log-rank (Mantel-Cox) test (survival curves). (a) Body weight (BW); (b) cutaneous temperature change; (c) survival.

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