Fig. 2: Representative clinical symptoms of K18-hACE2 mice after infections of SARS-CoV-2 and variants. | Nature Communications

Fig. 2: Representative clinical symptoms of K18-hACE2 mice after infections of SARS-CoV-2 and variants.

From: SARS-CoV-2 B.1.1.7 (alpha) and B.1.351 (beta) variants induce pathogenic patterns in K18-hACE2 transgenic mice distinct from early strains

Fig. 2: Representative clinical symptoms of K18-hACE2 mice after infections of SARS-CoV-2 and variants.

K18-hACE2 mice of both sexes (~1:1 ratio) were infected intranasally with USA-WA1/2020 (WA) of lineage A bearing 614D at 104 TCID50/mouse, New York-PV09158/2020 (NY) of lineage B.1.3 bearing 614G at 103 TCID50/mouse, USA/CA_CDC_5574/2020 (CA) of lineage B.1.1.7 at 102 TCID50/mouse or hCoV-19/South Africa/KRISP-EC-K005321/2020 (SA) of lineage B.1.351 at 102 TCID50/mouse, respectively. Representative images of infected mice and damaged tissues are shown. (a) inflamed eyes; (b) normal brain; (c) infected brains with hemorrhage; (d) infected lungs with hemorrhage; (e) infected intestines with excessive gas; (f) infected enlarged bladders; (g) normal spleen, stomach and kidney; (h) swollen stomachs and hemorrhagic spleen after infection; (i) swollen kidneys of infected female mice. Arrows indicate where the lesions exist.

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