Fig. 5: Chemokine profile induced by infections of SARS-CoV-2 or variants. | Nature Communications

Fig. 5: Chemokine profile induced by infections of SARS-CoV-2 or variants.

From: SARS-CoV-2 B.1.1.7 (alpha) and B.1.351 (beta) variants induce pathogenic patterns in K18-hACE2 transgenic mice distinct from early strains

Fig. 5

K18-hACE2 mice of both sexes (~1:1 ratio) were infected intranasally with USA-WA1/2020 (WA) of lineage A bearing 614D, New York-PV09158/2020 (NY) of lineage B.1.3 bearing 614G, USA/CA_CDC_5574/2020 (CA) of lineage B.1.1.7 or hCoV-19/South Africa/KRISP-EC-K005321/2020 (SA) of lineage B.1.351 at indicated doses in an ABSL-3 biocontainment. Cytokines in lung and liver homogenates harvested at indicated days post infection (dpi) were measured, including (a) IL-10; (b) IL-13; (c) MCP-1; (d) MIP-1α; (e) MIP-1β; (f) MIP-2; and (g) RANTES. Results combining two independent experiments are shown. Data of individual mice are shown with mean ± s.e.m of 7–9 mice/time point/group (WA (614D): n = 8 mice/time point/group for dpi 3 and dpi 6; NY (614G): n = 7 mice/group for dpi 3 and n = 8 mice/time point for dpi 6; CA (B.1.1.7): n = 7 mice/group for dpi 3 and n = 9 mice/group for dpi 5–7; SA (B.1.351): n = 7 mice/time point/group for dpi 3 and dpi 5–7; naïve: n = 7 mice/group). Dotted horizontal lines indicate the limit of detection.

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