Fig. 4: MSCs are cleared despite the absence of cytotoxic cells or allorecognition.
From: Mesenchymal stromal cell apoptosis is required for their therapeutic function
a Bioluminescent images of the whole body and dissected lungs, and quantification of total flux following i.v. administration of human MSCs into BALB/c mice. Data expressed as mean ± SEM, n = 3 mice per group, representative of two independent experiments. p values by two-way ANOVA (Tukey’s post hoc test). b Bioluminescent images of unsensitised (UNS) versus OVA-sensitised (SEN) mice injected with human MSCs following intranasal challenge with OVA. Representative images of two independent experiments (n = 3 mice per group) c Administration of human MSCs (xenogeneic) versus BALB/c MSCs (syngeneic) versus C57BL/6 MSCs (allogeneic) into BALB/c mice. Bioluminescent images and quantification of total flux with data expressed as mean ± SEM, three mice per group, representative of two independent experiments. p values for 48 h by two-way ANOVA (Tukey’s post hoc test). d Administration of human MSCs into BALB/c versus NSG versus BRGS mice. Bioluminescent images and quantification of total flux with data expressed as mean ± SEM, n = 3 mice per group, representative of two independent experiments. p values for 48 h by two-way ANOVA (Tukey’s post hoc test). e Total cell number of various myeloid cell populations measured in lungs of BALB/c, NSG and BGRS mice. Data expressed as mean ± SEM, n = 3 mice per group, representative of two independent experiments. p values by one-way ANOVA (Tukey’s post hoc test). Source data are provided as a Source Data file.
