Fig. 6: Prognostic signature of FAS module. | Nature Communications

Fig. 6: Prognostic signature of FAS module.

From: Discovery of putative tumor suppressors from CRISPR screens reveals rewired lipid metabolism in acute myeloid leukemia cells

Fig. 6: Prognostic signature of FAS module.

a Heatmap of mixed Z-scores for genes implicated in the genetic interaction network. Top, common AML lesions. b Mixed Z-score of FASN in AML cell lines vs. age of patient from which cell lines were derived. Blue, FASTS cells. c Age distribution of AML patients in three public tumor genomics cohorts. Red denotes OSHU, green denotes TARGET, and blue represents TCGA. d Hazard ratios (95% CI; univariate Cox proportional-hazards test) for expression of genes in (a), using genomics and survival data from TARGET. The dot represents the HR value indicated on the right. The 95% CI range for each point is indicated on the left. Genes indicated in red represent genes with significant HR less than 1 and are used for analysis in (e). e Hierarchical clustering of gene expression in TARGET, using the four genes with negative HR. Green, high expression cluster. Blue, others. f Kaplan–Meier survival analysis of AML patients in TARGET, comparing patients in high expression cluster vs. others. Shaded regions represent 95% CI of the curve. The number of independent patients analyzed in (d–f) = 145.

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