Fig. 3: Intratumour heterogeneity of somatic copy-number alterations in the neuroblastoma cohort. | Nature Communications

Fig. 3: Intratumour heterogeneity of somatic copy-number alterations in the neuroblastoma cohort.

From: Spatial and temporal intratumour heterogeneity has potential consequences for single biopsy-based neuroblastoma treatment decisions

Fig. 3

a Overview of Somatic copy-number alterations (SCNA) events per-cytoband aggregated across 9 patients. Amplifications and gains are visible in the upper half, loss of heterozygosity (LOH) and deep losses in the lower half of the plot. Clinically relevant chromosome regions 1p36, 2p24, 11q and 17q are highlighted in red at the top. Mirrored subclonal allelic imbalances (MSAI) are indicated by grey shading. MYCN locus: 2p24 b Fraction of chromosomes affected by segmental or whole-chromosome gains and losses are depicted for the low-and intermediate-risk patients (CB1007, CB1009) and the high-risk patients (CB1001, CB1002, CB1003, CB1004, CB1005, CB1010).

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