Fig. 1: Asymmetric construction of all-carbon quaternary stereocenters via enantioselective functionalizations of α-branched ketones.

a Asymmetric construction of quaternary stereocenters of activated ketones. b Asymmetric construction of quaternary stereocenters of α-branched cyclic ketones. c Unsaturation-enabled asymmetric Mannich reaction of α-branched acyclic ketones. d Asymmetric construction of acyclic quaternary stereocenters of α-alkynyl acyclic ketones.